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In 1960, John F. Kennedy was struggling. In the throes of a physically and emotionally difficult presidential campaign, he was facing a great unknown: the first-ever televised presidential debate against the formidable Richard Nixon. As Dwight Eisenhower’s vice president, Nixon was a policy wonk and very skilled in debates.

On top of that, Kennedy had a secret. He had known for some time that he was suffering from a chronic endocrine disease. JFK suffered from Addison’s disease, otherwise known as primary failure of the adrenal glands. This disease causes many systemic effects and is often fatal without supplementation of cortisol, which was synthesized as Prednisone in the late 1940s. 

Taking it restored Kennedy’s health but left him with some of the other effects of the disease, including a suntanned appearance. This, more than anything he said in that fateful televised debate, is said to have led to his victory in the election. When compared to Nixon, who was pale and sweating, Kennedy won the day.

Adrenal insufficiency is very much a real and serious illness, but it is exceedingly rare. Since 1998, another ‘ailment’ of sorts has entered the lexicon that bears a resemblance to Addison’s disease but has a much more nebulous history and has been a source of some controversy.

Where Is Adrenal Fatigue?

Just over two decades ago, a chiropractor and naturopath first coined the term “adrenal fatigue” to identify below-optimal adrenal function resulting from stress that is different from Addison’s disease.

Per the original definition, adrenal fatigue is said to be the result of repeated stress of daily life on the adrenal glands, resulting in an imbalance in the ability of the glands to produce suitable quantities of hormones. 

As many other naturopaths have taken up the diagnosis, it has spread widely across the Internet. However, conventional medicine does not yet recognize it as a distinct syndrome. In fact, a literature review published in 2016 in BMC Endocrine Disorders found “no substantiation that ‘adrenal fatigue’ is an actual medical condition.” 

Symptoms of Adrenal Fatigue

Like so many other “new” diseases, adrenal fatigue is defined in such a way to be very vague and apply to just about everyone. Consider the difference in the definition of Addison’s disease.

Addison’s is characterized by progressive anemia, low blood pressure, great weakness, and bronze discoloration of the skin. It’s caused by inadequate secretion of hormones by the adrenal cortex.

Adrenal fatigue is a collection of signs and symptoms, known as a syndrome, that results when the adrenal glands function below the necessary level. Most commonly associated with intense or prolonged stress, it can also arise during or after acute or chronic infections, especially respiratory infections such as influenza, bronchitis, or pneumonia.

The paramount symptom is fatigue that is not relieved by sleep, but it is not a readily identifiable entity. You may look and act relatively normal, but feel a general sense of unwellness, tiredness, or “gray” feelings. People experiencing adrenal fatigue often have to use coffee or other stimulants to get going in the morning and to prop themselves up during the day.

Medical Diseases vs. Syndromes

Addison’s is a medical disease, meaning it has quantifiable symptoms that can be measured to both define the illness (e.g.; low blood counts and altered vital signs) and explain it (e.g. hormone levels).

A syndrome, on the other hand, is vague, non-specific, and defined in such a way that it can apply to almost anyone on any given day. Who hasn’t needed a coffee on some mornings to feel more awake? Who hasn’t felt more tired when in a period of stress affecting their sleep quality?

The rationale for why so many people, including athletes, have come to grasp at adrenal fatigue is simple: people want an easy answer for what ails them. And this is especially true when the person providing the answer can also provide a solution.

How is Adrenal Fatigue Treated?

If you go to your physician with the symptoms of adrenal fatigue, the physician is going to examine you, do some tests, and likely tell you that you are stressed. They might suggest that you modify your lifestyle to decrease that stress—perhaps by simply adopting better eating and sleeping habits.

For most patients, however, this is extremely unsatisfactory advice.

It is the latter part of this statement that really explains why adrenal fatigue has become so popular. Health experts who diagnose and “treat” adrenal fatigue may do so with a concoction of (often expensive) supplements. For example, $40 will buy you a fifty-day supply of one such supplement, which contains some minerals and vitamin C—neither of which has anything to do with actual adrenal gland function. People essentially pay millions of dollars a year for these things because they are convinced they have a problem that doesn’t exist.

Dr. Lisa Kosmiski is an endocrinologist in Denver, Colorado, and increasingly sees patients who come to her convinced they have some kind of glandular dysfunction.

“I’ve had a couple of patients insist they had adrenal fatigue, and I felt pressured to treat them,” she says. “I did ACTH stimulation tests (tests to determine adrenal gland function) on both, and of course, they were normal.” 

Dr. Kosmiski is frustrated by the growth of pseudoscience that leads patients to believe that she is somehow deceiving them. “Some individuals require a simple answer for whatever ails them and an answer that involves no work on their part, such as becoming more physically active,” she says. 

“We are seeing more and more women who say their clearly normal thyroid tests are not normal for them, and more and more men who say their normal testosterone levels are not normal for them.”

She wishes that more patients would take the time to research the ‘diseases’ and, more importantly, the ‘cures’ that they are being sold.

What To Do if You Experience Symptoms

There is no doubt that the symptoms of fatigue and stress are real. But instead of writing it off as “adrenal fatigue,” try to find out the root of the problem: Are you overtraining? Are there issues in their work or personal lives that may be impacting their ability to sleep? Are they simply not eating well? 

Sometimes a completely different endocrine issue is at play. Hypothyroidism, more common in women, can cause many of the same symptoms experienced with adrenal fatigue. A visit to the doctor is probably a good idea if you’re symptoms don’t subside. 

While the idea of adrenal fatigue may make you feel better by providing an answer to your symptoms, it won’t fix you. Until you resolve the real cause of your symptoms, no pricey supplements claiming to “cure” adrenal fatigue will do much for you—other than deprive you of your hard-earned income.

References

Cedars-Sinai Staff. (2018, January 18). Debunking Adrenal Fatigue. Retrieved from https://www.cedars-sinai.org/blog/debunking-adrenal-fatigue.html

Seaborg, Eric. (2017, September). The Myth of Adrenal Fatigue. Retrieved from https://endocrinenews.endocrine.org/myth-adrenal-fatigue/

Cadegiani F. et al. (2017, September). Adrenal fatigue does not exist: a systematic review. Retrieved from https://endocrinenews.endocrine.org/myth-adrenal-fatigue/